Procaine, a State-Dependent Blocker, Inhibits HERG Channels by Helix Residue Y652 and F656 in the S6 Transmembrane Domain
Author:
Publisher
Japanese Pharmacological Society
Subject
Pharmacology,Molecular Medicine
Link
https://www.jstage.jst.go.jp/article/jphs/123/1/123_13007FP/_pdf
Reference43 articles.
1. 1 Sanquinetti MC, Jiang C, Curran ME, Keating MT. A mechanistic link between an inherited and an acquired cardiac arrhythmia: HERG encodes the IKr potassium channel. Cell. 1995;81:299–307.
2. 2 Jones EM, Roti EC, Wang J, Delfosse SA, Robertson GA. Cardiac IKr channels minimally comprise hERG 1α and 1β subunits. J Biol Chem. 2004;279:44690–44694.
3. 3 Mitcheson JS, Chen J, Sanquinetti MC. Trapping of a methanesulfonanilide by closure of the HERG potassium channel activation gate. J Gen Physiol. 2000;115:229–240.
4. 4 Mitcheson JS, Perry MD. Molecular determinants of high affinity drug binding to HERG channels. Curr Opin Drug Discov Devel. 2003;6:667–674.
5. 5 Mitcheson JS, Chen J, Lin M, Culberson C, Sanguinetti MC. A structural basis for drug-induced long QT syndrome. Proc Natl Acad Sci U S A. 2000;97:12329–12333.
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