Hydroxyzine, a First Generation H1-Receptor Antagonist, Inhibits Human Ether-a-go-go–Related Gene (HERG) Current and Causes Syncope in a Patient With the HERG Mutation-Reference-Cited by-同舟云学术

Hydroxyzine, a First Generation H1-Receptor Antagonist, Inhibits Human Ether-a-go-go–Related Gene (HERG) Current and Causes Syncope in a Patient With the HERG Mutation

Published:2008 Issue:4 Volume:108 Page:462-471
ISSN:1347-8613
Container-title:Journal of Pharmacological Sciences
language:en
Short-container-title:J Pharmacol Sci

Author:

Sakaguchi Tomoko,Itoh Hideki,Ding Wei-Guang,Tsuji Keiko,Nagaoka Iori,Oka Yuko,Ashihara Takashi,Ito Makoto,Yumoto Yoshihiro,Zenda Naoko,Higashi Yukei,Takeyama Youichi,Matsuura Hiroshi,Horie Minoru

Publisher

Japanese Pharmacological Society

Subject

Pharmacology,Molecular Medicine

Reference26 articles.

1. Drug-Induced Prolongation of the QT Interval

2. Blockade of HERG channels expressed in Xenopus oocytes by the histamine receptor antagonists terfenadine and astemizole

3. 3 Roy M, Dumaine R, Brown AM. HERG, a primary human ventricular target of the nonsedating antihistamine terfenadine. Circulation. 1996;94:817–823.

4. Human Ether-a-gogo Related Gene (HERG) K Channels as Pharmacological Targets

5. Torsades de pointes occurring in association with terfenadine use

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