A review on the dosimetrical and radiobiological prediction of radiation-induced hypothyroidism in radiation therapy of head-and-neck cancer, breast cancer, and Hodgkin’s lymphoma survivors

Author:

Namdar Aysan Mohammad12,Mohammadzadeh Mohammad3,Okutan Murat4,Mesbahi Asghar56

Affiliation:

1. Immunology Research Center , Tabriz University of Medical Sciences , Tabriz , Iran

2. Medical Physics Department, Medical School , Tabriz University of Medical Sciences , Tabriz , Iran .

3. Radiation Oncology Department, Imam Reza Hospital, Medical School , Tabriz University of Medical Sciences , Tabriz , Iran .

4. Istanbul University , Oncology Institute, Department of Medical Physics , Istanbul , Turkey .

5. Medical Radiation Sciences Research Team , Tabriz University of Medical Sciences , Tabriz , Iran

6. Molecular Medicine Research Center, Institute of Biomedicine , Tabriz University of Medical Sciences , Tabriz , Iran .

Abstract

Abstract A review on the radiobiological modeling of radiation-induced hypothyroidism after radiation therapy of head-and-neck cancers, breast cancer, and Hodgkin’s lymphoma is presented. The current review is based on data relating to dose-volume constrains and normal tissue complication probability (NTCP) as a function of either radiobiological or (pre)treatment-clinical parameters. Also, these data were explored in order to provide more helpful criteria for radiobiological optimization of treatment plans involving thyroid gland as a critical normal organ.

Publisher

Walter de Gruyter GmbH

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