Correlations between Biochemical Markers in Thyroid Pathology with those in Carbohydrates Metabolism

Abstract

Abstract Thyroid dysfunction is increasingly found in patients with diabetes. Diabetes can affect thyroid function to a variable extent and unrecognized thyroid dysfunction, not only worsens metabolic control, but also prevents the management of diabetes. The aim of this study was to screen the incidence of thyroid disease in Constanta County, Romania in patients diagnosed with type II diabetes, in order to assess the tendency to associate thyroid hormone dysfunction with the diabetic process by correlating glycemic parameters and thyroid profile in serum. The study included a number of 153 patients who presented within 3 months for blood tests, in compliance with GDPR rules. The following parameters were processed from these patients: FT3 - free triiodothyronine, FT4 - free thyroxine, TSH - thyroid stimulating hormone, Anti-TPO - thyroid peroxidase antibodies (anti-thyroid peroxidase), Serum glucose, Glycosylated haemoglobin - HbA1C. In patients of both sexes studied, the mean TSH was 3.15 IU / ml, males’ TSH mean being 2.82 IU / ml and higher, but not above the maximum limit. Blood glucose ranged from an average of 92.11 mg / dl in the 153 patients, 92.41 mg / dl in male patients and 93.82 mg / dl in female patients. Glycated haemoglobin (%) ranged from 6.79% in female patients to 6.21% in male patients, with a mean of 6.5%. Pathology derived from disorders of carbohydrate metabolism may be present in patients with thyroid changes.