Skin Decontamination with Mineral Cationic Carrier Against Sarin Determined In Vivo

Abstract

Skin Decontamination with Mineral Cationic Carrier Against Sarin DeterminedIn VivoOur Institute's nuclear, biological, and chemical defense research team continuously investigates and develops preparations for skin decontamination against nerve agents. In thisin vivostudy, we evaluated skin decontamination efficacy against sarin by a synthetic preparation called Mineral Cationic Carrier (MCC®) with known ion exchange, absorption efficacy and bioactive potential. Mice were treated with increasing doses of sarin applied on their skin, and MCC® was administered immediately after contamination. The results showed that decontamination with MCC® could achieve therapeutic efficacy corresponding to 3 x LD50of percutaneous sarin and call for further research.