Affiliation:
1. Department of Hematology and Transfusiology, University Hospital Martin and Jessenius Faculty of Medicine in Martin, Comenius University in Bratislava , Martin , Slovakia
2. Department of Medical Biology, Jessenius Faculty of Medicine in Martin, Comenius University in Bratislava , Martin , Slovakia
Abstract
Abstract
Hematological malignancies represent a heterogeneous group of diseases that may have overlapping clinical manifestations. Successful and optimal management depends on early and accurate diagnosis of the disease. Differential diagnosis therefore requires methods of morphology, immunohistochemistry, flow cytometry, and also molecular and cytogenetic examinations. Molecular diagnostic techniques are becoming more accurate and sophisticated, which is why nowadays hematopathological diagnosis relies heavily on molecular and cytogenetic analyses. They are beneficial not only for diagnosis, but also for evaluating prognostic and risk markers, as well as treatment monitoring. This article presents an overview of selected hematological malignancies – mature lymphoid neoplasms, multiple myelomas, myeloproliferative neoplasms, myelodysplastic syndromes, and acute myeloid leukemias; their molecular pathology, risk and prognostic markers. Understanding of the biologic basis leds to a targeted therapy development for the treatment of these diseases.
Reference31 articles.
1. Zhang N, Wu J, Wang Q et al. Global burden of hematologic malignancies and evolution patterns over the past 30 years. Blood Cancer J. 2023; 13(1): 82.
2. Rao D, Said J. Pathology and Molecular Pathology of Hematologic Malignancies
3. Beck RC, Kim AS, Goswami RS et al. A Recommended Curriculum From The Society for Hematopathology and the Association for Molecular Pathology. Am J Clin Pathol 2020;154:149–177
4. Mukkamalla SKR, Taneja A, Malipeddi D et al. Chronic Lymphocytic Leukemia. StatPearls Publishing; 2024 Jan-.
5. Wainman LM, Khan WA, Kaur P. Chronic Lymphocytic Leukemia: Current Knowledge and Future Advances in Cytogenomic Testing. In: Sergi CM, editor. Advancements in Cancer Research. Brisbane (AU): Exon Publications; Online first 08 Feb 2023. p. 93–106