Correlation between brush cytology results and histopathological examination in diagnostic evaluation of precancerous conditions and laryngeal cancer: A prospective study-Reference-Cited by-同舟云学术

Correlation between brush cytology results and histopathological examination in diagnostic evaluation of precancerous conditions and laryngeal cancer: A prospective study

Published:2022-01-01 Issue:1 Volume:76 Page:149-156
ISSN:1732-2693
Container-title:Postępy Higieny i Medycyny Doświadczalnej
language:en
Short-container-title:

Author:

Lepka Paulina¹^ORCID,Zatoński Tomasz²^ORCID,Barnaś Szczepan¹^ORCID,Lepka Piotr³^ORCID,Hałoń Agnieszka⁴^ORCID

Affiliation:

1. Clinic of Otolaryngology Head and Neck Surgery , 4th Military Clinical Hospital with Polyclinic in Wroclaw , Poland

2. Department and Clinic of Otolaryngology Head and Neck Surgery , Wroclaw Medical University , Wroclaw , Poland

3. Division of Surgical Oncology, Gynecological Oncology, Chemotherapy and Department of Oncology , Wroclaw Medical University , Lower Silesian Oncology Center in Wroclaw , Poland

4. Department of Pathomorphology and Oncological Cytology , Wroclaw Medical University, Head of the Department , Poland

Abstract

Abstract Introduction The aim of the paper was to demonstrate that brush cytology can be useful in diagnostic evaluation of precancerous states and laryngeal cancer. Materials and Methods Ninety-two patients were analyzed. The control group included patients with benign laryngeal lesions, while the study group was composed of patients in whom a precancerous condition or laryngeal cancer was suspected. Material for histopathological and cytological examination was collected during a laryngeal microsurgery. The authors analyzed the consistency of the results of cytological and histopathological examination in the diagnostic evaluation of precancerous conditions and laryngeal cancer. Results Comparing diagnoses based on cytological examination with the results of histopathological examinations, the authors observed that there was a strong and statistically significant (p<0.001) correlation between the results. The accuracy of brush cytology in the conducted study indicates that the sensitivity and specificity of the test reaches 90.09% and 93.5% with 4 false negative and 3 false positive results. Positive prediction reached 93% and negative prediction reached 91.5%. Conclusions Brush cytology of the larynx may be useful in screening and as an auxiliary test in diagnostic evaluation of precancerous conditions and laryngeal cancer.

Publisher

Walter de Gruyter GmbH

Subject

Infectious Diseases,Microbiology (medical)

Link

https://www.sciendo.com/pdf/10.2478/ahem-2022-0015

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