Can colistin susceptibility results determined in multidrug resistant Gram-negative bacteria be used for polymyxin B?-Reference-Cited by-同舟云学术

Can colistin susceptibility results determined in multidrug resistant Gram-negative bacteria be used for polymyxin B?

Published:2023-01-01 Issue:1 Volume:77 Page:125-132
ISSN:1732-2693
Container-title:Postępy Higieny i Medycyny Doświadczalnej
language:en
Short-container-title:

Author:

Adaleti Rıza¹^ORCID,Kansak Nilgün²^ORCID,Çalık Şeyma³^ORCID,Arıcı Neslihan²^ORCID,Şenbayrak Seniha⁴^ORCID,Aksaray Sebahat¹^ORCID

Affiliation:

1. University of Health Sciences , Hamidiye Medical Faculty, Department of Medical Microbiology , Istanbul , Turkey

2. University of Health Sciences , Haydarpaşa Numune Training and Research Hospital , Laboratory of Medical Microbiology , Istanbul , Turkey

3. Ministry of Health, Directorate of Public Health , Amasya , Turkey

4. University of Health Sciences , Hamidiye Medical Faculty, Department of Infectious Diseases and Clinical Microbiology , Istanbul , Turkey

Abstract

Abstract Introduction The present study aimed to compare the MIC values of colistin and polymyxin B in fermentative and non-fermentative Gram-negative bacteria and to examine whether the susceptibility results determined with colistin can be used for polymyxin B. Materials and Methods A total of 268 strains of Escherichia coli (E. coli), Klebsiella pneumoniae (K. pneumoniae), Pseudomonas aeruginosa (P. aeruginosa), and Acinetobacter baumannii (A. baumannii) isolates were included in the study. The reference broth microdilution and the results were evaluated according to CLSI recommendations. Results Of the 268 strains, 40.7% were found to be colistin resistant and 34% polymyxin B resistant. Essential agreement (EA) and categorical agreement (CA) ratios for all isolates were found to be 81.3% and 85.1%, respectively. Identical MIC values were found for colistin and polymyxin B in 104 isolates (38.8%), and this rate was 31.1% and 48.7% in Enterobacterales and non-fermentative bacteria, respectively. Colistin resistance rates were 25.4% for E. coli, 67.4% for K. pneumoniae, 23.8% for P. aeruginosa, and 31.5% for A. baumannii. Polymyxin B resistance rates were 18.6% for E. coli, 64.1% for K. pneumoniae, 19% for P. aeruginosa, and 16.7% for A. baumannii. Conclusion According to the results of the study, it was concluded that the MIC values of colistin and polymyxin B antibiotics in all bacteria were not compatible with each other. Colistin susceptibility results cannot be used for treatment with polymyxin B, despite CLSI's recommendation.

Publisher

Walter de Gruyter GmbH

Subject

Infectious Diseases,Microbiology (medical)

Link

https://www.sciendo.com/pdf/10.2478/ahem-2023-0017

Reference14 articles.

1. Landman D, Georgescu C, Martin DA, Quale J. Polymyxins revisited. Clin Microbiol Rev. 2008; 21:449–65.

2. Koch-Weser J, Sidel VW, Federman EB, Kanarek P, Finer DC, Eaton AE. Adverse effects of sodium colistimethate. Manifestations and specific reaction rates during 317 courses of therapy. Ann Intern Med. 1970;72:857–868.

3. Clinical and Laboratory Standards Institute (CLSI). M100. Performance Standards for Antimicrobial Susceptibility Testing. 2022; 32th ed, Wayne, PA. Available at: http://em100.edaptivedocs.net/GetDoc.aspx?doc=CLSI%20M100%20ED32:2022&xormat=SPDF&src=BB (Accessed August 11, 2023).

4. European Committee on Antimicrobial Susceptibility Testing. Break point tables for interpretation of MICs and zone diameters. 2023; Version 13.1, 2023. Available at: https://www.eucast.org/fileadmin/src/media/PDFs/EUCAST_files/Breakpoint_tables/v_13.1_Breakpoint_Tables.pdf (Accessed August 11, 2023).

5. Falagas ME, Kasiakou SK. Colistin: the revival of polymyxins for the management of multidrug-resistant gram-negative bacterial infections [published correction appears in Clin Infect Dis. 2006; 42:1819. Dosage error in article text]. Clin Infect Dis. 2005;40:1333–1341.