CD8+ T regulatory cells in lupus-Reference-Cited by-同舟云学术

CD8+ T regulatory cells in lupus

Published:2021-09-01 Issue:3 Volume:2 Page:147-156
ISSN:2719-4523
Container-title:Rheumatology and Immunology Research
language:en
Short-container-title:

Author:

Singh Ram P.¹²,Bischoff David S.¹³,Hahn Bevra H.²³

Affiliation:

1. Research Service, Veteran Administration Greater Los Angeles Healthcare System , Los Angeles , CA , USA

2. Department of Medicine, Division of Rheumatology , University of California , Los Angeles , USA

3. Department of Medicine , University of California , Los Angeles, Los Angeles , CA , USA

Abstract

Abstract T regulatory cells (Tregs) have a key role in the maintenance of immune homeostasis and the regulation of immune tolerance by preventing the inflammation and suppressing the autoimmune responses. Numerical and functional deficits of these cells have been reported in systemic lupus erythematosus (SLE) patients and mouse models of SLE, where their imbalance and dysregulated activities have been reported to significantly influence the disease pathogenesis, progression and outcomes. Most studies in SLE have focused on CD4+ Tregs and it has become clear that a critical role in the control of immune tolerance after the breakdown of self-tolerance is provided by CD8+ Tregs. Here we review the role, cellular and molecular phenotypes, and mechanisms of action of CD8+ Tregs in SLE, including ways to induce these cells for immunotherapeutic modulation in SLE.

Publisher

Walter de Gruyter GmbH

Link

https://www.degruyter.com/document/doi/10.2478/rir-2021-0021/pdf

Reference134 articles.

1. Crispin JC, Kyttaris VC, Terhorst C, et al. T Cells as Therapeutic Targets in SLE. Nat Rev Rheumatol. 2010;6:317–125.

2. Crow MK. Collaboration, Genetic Associations, and Lupus Erythematosus. N Engl J Med. 2008;358:956–961.

3. Hahn BH. Lessons in Lupus: The Mighty Mouse. Lupus. 2001;10:589–593.

4. Filaci G, Bacilieri S, Fravega M, et al, Impairment of CD8+ T Suppressor Cell Function in Patients with Active Systemic Lupus Erythematosus. J Immunol. 2001;166:6452–6457.

5. Karpouzas GA, La Cava A, Ebling FM, et al., Differences Between CD8+ T Cells in Lupus-Prone (NZB x NZW)F1 Mice and Healthy (BALB/c x NZW)F1 Mice May Influence Autoimmunity in the Lupus Model. Eur J Immunol. 2004;34:2489–2499.

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