Epigenetic markers associated with schistosomiasis-Reference-Cited by-同舟云学术

Epigenetic markers associated with schistosomiasis

Published:2021-02-10 Issue:1 Volume:58 Page:28-40
ISSN:1336-9083
Container-title:Helminthologia
language:en
Short-container-title:

Author:

Gomes Assenço R. A.¹,Alves Mota E.²,De Oliveira V. F.²³,De Castro Borges W.¹⁴,Guerra-Sá R.¹²

Affiliation:

1. Programa de Pós-Graduação em Ciências Farmacêuticas (CiPharma), Escola de Farmácia , Universidade Federal de Ouro Preto . Ouro Preto, CEP , Minas Gerais , Brazil

2. Laboratório de Bioquímica e Biologia Molecular (LBBM), Departamento de Ciências Biológicas, Instituto de Ciências Exatas e Biológicas , Universidade Federal de Ouro Preto . Ouro Preto, CEP , Minas Gerais , Brazil

3. Laboratório de Biologia Molecular Aplicada ao Diagnóstico (LABMAD), Departamento de Análises Clínicas e Toxicológicas, Faculdade de Ciências Farmacêuticas , Universidade de São Paulo . São Paulo, CEP , São Paulo , Brazil

4. Laboratório de Enzimologia e Proteômica (LEP), Departamento de Ciências Biológicas, Instituto de Ciências Exatas e Biológicas , Universidade Federal de Ouro Preto . Ouro Preto, CEP , Minas Gerais , Brazil

Abstract

Summary It is important to consider the use of the epigenome as source of complementary data for genome knowledge, which is suitable for the diagnosis of schistosomiasis. Usually, a laboratory diagnosis of schistosomiasis is performed by means of 1. Egg detection in the stool or urine by microscopy remains with limited sensitivity; 2. Immunological screening, in which positivity persists after treatment, and 3. Molecular appraisals prevail over the disadvantages of the currently used methods. In this sense, molecular methodologies are being developed based on epigenetic biomarkers, aiming to improve the diagnosis of the disease and clinical treatment as early as possible to prevent the occurrence of serious liver damage.

Publisher

Walter de Gruyter GmbH

Subject

Animal Science and Zoology,Parasitology

Link

https://www.sciendo.com/pdf/10.2478/helm-2021-0009

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