The role of factor XIII-A in the development of inflammatory skin lesions-Reference-Cited by-同舟云学术

The role of factor XIII-A in the development of inflammatory skin lesions

Published:2014-09-01 Issue:9 Volume:9 Page:869-873
ISSN:2391-5412
Container-title:Open Life Sciences
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Author:

Włodarczyk Marcin¹,Sobolewska Aleksandra¹,Lesiak Aleksandra²,Narbutt Joanna²

Affiliation:

1. 1Students’ Faculty at the Department of Dermatology and Venereology, Medical University of Lodz, 90-647, Lodz, Poland

2. 2Department of Dermatology and Venereology, Medical University of Lodz, 90-647, Lodz, Poland

Abstract

AbstractFactor XIII (FXIII) is a unique clotting factor activated in the last stage of the coagulation cascade, with multiple other plasmatic and cellular functions, outside of the traditional homeostasis. Literature data show that FXIII is expressed in skin lesions in the course of various inflammatory skin disorders. Dermis contains a series of macrophages and dendritic cells, which express different phenotypes including FXIII. Increased levels of FXIII-positive cells are present in specific cutaneous inflammatory and fibrotic conditions. The aim of this review is to provide the relationship between FXIII and the development of the inflammatory skin lesions.

Publisher

Walter de Gruyter GmbH

Subject

General Agricultural and Biological Sciences,General Immunology and Microbiology,General Biochemistry, Genetics and Molecular Biology,General Neuroscience

Link

http://link.springer.com/content/pdf/10.2478/s11535-014-0319-9.pdf

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