Kainic acid lesion-induced spatial memory deficits of rats-Reference-Cited by-同舟云学术

Kainic acid lesion-induced spatial memory deficits of rats

Published:2009-06-01 Issue:2 Volume:4 Page:179-185
ISSN:2391-5412
Container-title:Open Life Sciences
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Author:

Hritcu Lucian¹,Nabeshima Toshitaka²

Affiliation:

1. 1Department of Biology, “Alexandru Ioan Cuza” University, 700506, Iasi, Romania

2. 2Department of Chemical Pharmacology, Meijo University, Graduate School of Pharmaceutical Sciences, 468-8503, Nagoya, Japan

Abstract

AbstractThe effects of lesioning the ventral tegmental area (VTA) or substantia nigra (SN) neurons by means of bilateral stereotaxic microinjections of kainic acid (KA) (0.4 mM) were investigated to clarify the role of the VTA and the SN neurons in learning and memory processes. The present study demonstrates that KA in the SN and the VTA lesioned rats significantly decreased spontaneous alternation in Y-maze task, working memory and reference memory in radial 8 arm-maze task, suggesting effects on spatial memory performance. Our findings provide further support for the role of the VTA and the SN neurons in processing and storage of information.

Publisher

Walter de Gruyter GmbH

Subject

General Agricultural and Biological Sciences,General Immunology and Microbiology,General Biochemistry, Genetics and Molecular Biology,General Neuroscience

Link

http://link.springer.com/content/pdf/10.2478/s11535-009-0001-9.pdf

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