Role of HLA-G and other immune mechanisms in pregnancy

Author:

Durmanova Vladimira1,Homolova Monika1,Drobny Juraj2,Shawkatova Ivana1,Buc Milan1

Affiliation:

1. 1Institute of Immunology, School of Medicine, Comenius University, 813 72, Bratislava, Slovakia

2. 21st Department of Obstetrics and Gynaecology, University Hospital, School of Medicine, Comenius University, 851 07, Bratislava, Slovakia

Abstract

AbstractPregnancy loss (abortion) and pre-eclampsia represent the most common disorders in pregnant women. Besides infection, there are anatomical, endocrinological, genetic and immunological factors that can induce pregnancy disorders. Because the exact mechanisms of physiological pregnancy maintenance are still not clearly understood, the search for genes and proteins fulfilling this role is still in progress. One of the immune molecules that plays a beneficial role in pregnancy is the nonclassical HLA-G molecule. The molecule is mainly expressed on trophoblast cells in the foetal placenta and induces the immune tolerance of the foetus via its interaction with inhibitory receptors on maternal NK cells and CD8+ T lymphocytes. In relation to pregnancy disorders, associations between HLA-G polymorphism, HLA-G level and HLA-G function were described. Thus, the HLA-G molecule can be used as a new diagnostic marker and, potentially, for the future therapy of pregnancy disorders.

Publisher

Walter de Gruyter GmbH

Subject

General Agricultural and Biological Sciences,General Immunology and Microbiology,General Biochemistry, Genetics and Molecular Biology,General Neuroscience

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