Lipopeptides as anti-infectives: a practical perspective-Reference-Cited by-同舟云学术

Lipopeptides as anti-infectives: a practical perspective

Published:2009-09-01 Issue:3 Volume:4 Page:258-273
ISSN:2391-5412
Container-title:Open Life Sciences
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Author:

Pirri Giovanna¹,Giuliani Andrea¹,Nicoletto Silvia¹,Pizzuto Lorena¹,Rinaldi Andrea²

Affiliation:

1. 1Research s& Development Unit, Spider Biotech S.r.l, I-10010, Colleretto Giacosa, Italy

2. 2Department of Biomedical Sciences and Technologies, University of Cagliari, 09042, Cagliari, Italy

Abstract

AbstractLipopeptide antibiotics represent an old class of antibiotics that were discovered over 50 years ago, which includes the old polymyxins but also new entries, such as the recently approved daptomycin. They generally consist of a hydrophilic cyclic peptide portion attached to a fatty acid chain which facilitates insertion into the lipid bilayer of bacterial membranes. This review presents an overview of this class of antibiotics, focusing on their therapeutic applications and putting particular emphasis on chemical modifications introduced to improve their activity.

Publisher

Walter de Gruyter GmbH

Subject

General Agricultural and Biological Sciences,General Immunology and Microbiology,General Biochemistry, Genetics and Molecular Biology,General Neuroscience

Link

http://link.springer.com/content/pdf/10.2478/s11535-009-0031-3.pdf

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