Effects of GABAB receptor antagonists CGP63360, CGP76290A and CGP76291A on learning and memory processes in rodents-Reference-Cited by-同舟云学术

Effects of GABAB receptor antagonists CGP63360, CGP76290A and CGP76291A on learning and memory processes in rodents

Published:2007-09-01 Issue:3 Volume:2 Page:280-293
ISSN:2391-5463
Container-title:Open Medicine
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Author:

Getova Damianka¹,Dimitrova Darinka¹

Affiliation:

1. 1Department of Pharmacology, Clinical Pharmacology and Drug Toxicology, Medical University, V. Aprilov str. 15A, Plovdiv, 4002, Bulgaria

Abstract

AbstractData in literature that use methods for studying the learning and memory processes suggest that GABA and especially GABAB receptor antagonists may be active against amnesia. The aim of our study was to examine the effects of three new GABAB-antagonists on learning and memory processes. Active and passive avoidance tests with negative reinforcement in rats were used. The rats treated with different GABAB receptor antagonists showed improving effects in both tests (active and passive avoidances)on learning as well as on memory retention. There are some differences in their activities, probably due to its chemical structures. The phosphinic analogue CGP63360A is potent to the point that the benzoic one CGP76290A and the left isomer of the benzoic analogue CGP76291A has no effect. It may be concluded that the obtained results on the GABAB receptor antagonists could contribute to their pharmacological characteristics and might be of interest for potential clinical implication.

Publisher

Walter de Gruyter GmbH

Subject

General Medicine

Link

http://link.springer.com/content/pdf/10.2478/s11536-007-0033-3.pdf

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