The effect of vitamin C on amiodarone-induced toxicity in rat thymocytes-Reference-Cited by-同舟云学术

The effect of vitamin C on amiodarone-induced toxicity in rat thymocytes

Published:2011-02-01 Issue:1 Volume:6 Page:58-63
ISSN:2391-5463
Container-title:Open Medicine
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Author:

Cekic S.¹,Pavlovic D.²,Sarac M.³,Kamenov B.⁴,Dimic A.⁵,Pavlovic V.¹

Affiliation:

1. 1Institute of Physiology, Medical Faculty University in Nis, 18000, Nis, Serbia

2. 2Institute of Biochemistry, Medical Faculty University in Nis, 18000, Nis, Serbia

3. 3Medical Faculty University in Nis, 18000, Nis, Serbia

4. 4Clinic of Pediatrics, Medical Faculty University in Nis, 18000, Nis, Serbia

5. 5Institute for Prevention, Treatment and Rehabilitation of Rheumatic and Cardiovascular Diseases, Medical Faculty University in Nis, 18000, Nis, Serbia

Abstract

AbstractAlthough, the antiarrhythmic effect of amiodarone (AMD) is well characterized, the mechanism of its toxicity on extracardiac tissues is still poorly understood. Several antioxidants have been shown to prevent AMD-induced toxicity by antioxidant and/or non-antioxidant mechanisms. In the current study, we evaluated the possible protective effect, in vitro, of vitamin C on AMD-induced toxicity in rat thymocytes. Rat thymocytes were cultured with increasing AMD concentrations (1–20 μM) with or without vitamin C (1000 μg/ml), for 24 hours. Cells treatment with AMD resulted in a concentration-dependent increase of hypodiploid cells and a significant decrease in cellular glutathione content. Vitamin C combined with AMD significantly decreased the proportion of hypodiploid cells and markedly increased the cellular glutathione content, compared with AMD treatment alone. These results suggest that treatment with vitamin C may prevent AMD-induced toxicity in rat thymocytes by restoring cellular glutathione content.

Publisher

Walter de Gruyter GmbH

Subject

General Medicine

Link

http://link.springer.com/content/pdf/10.2478/s11536-010-0050-5.pdf

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