Affiliation:
1. 1Department of Genetics and Microbiology, Faculty of Science, Charles University in Prague, 128 44, Praha 2, Czech Republic
Abstract
AbstractSurfactin, a highly powerful biosurfactant produced by various strains of the genus Bacillus, exhibits antibacterial, antiviral, antitumor and hemolytic action. This anionic cyclic lipopeptide is constituted by a heptapeptide interlinked with a β-hydroxy fatty acid. Due to its amhipathic nature surfactin incorporates into the phospholipid bilayer and induces permeabilization and perturbation of target cells. The rising antibiotic resistance as well as a number of remarkable surfactin activities shows that it deserves special interest and is considered as a candidate compound for combating several health related issues. In this review, the current state of knowledge of surfactin properties, biomedical potential and limitations for its application is presented.
Reference84 articles.
1. Boman H.G., Peptide antibiotics and their role in innate immunity, Annu. Rev. Immunol., 1995, 13, 61–92
2. Zasloff M., Innate immunity, antimicrobial peptides, and protection of the oral cavity, Lancet, 2002, 360, 1116–7
3. Zhang L., Falla T.J., Cationic antimicrobial peptides — An update, Expert. Opin. Invest. Drugs, 2004, 13, 97–106
4. Giuliani A., Pirri G., Fabiole Nicoletto S., Antimicrobial peptides: an overview of a promising class of therapeutics, Central European Journal of Biology, 2007, 2, 1–33
5. Arima K., Kakinuma A., Tamura G., Surfactin, a crystalline peptidelipid surfactant produced by Bacillus subtilis: isolation, characterization and its inhibition of fibrin clot formation, Biochem. Biophys. Res. Commun., 1968, 31, 488–494
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