Prenylated Benzophenones from <i>Vismia guianensis</i> Reduced Nematode Growth and Chemotaxis-Reference-Cited by-同舟云学术

Prenylated Benzophenones from Vismia guianensis Reduced Nematode Growth and Chemotaxis

Published:2022-02-01 Issue:1 Volume:54 Page:
ISSN:2640-396X
Container-title:Journal of Nematology
language:en
Short-container-title:

Author:

Gerald Carresse¹,Howard Rick-Kia¹,Adesina Rachael²,Hamer Seon³,Christian Omar E.²

Affiliation:

1. Department of Earth, Environmental and Geospatial Science, North Carolina Central University , Durham , NC 27707 North Carolina

2. Department of Chemistry and Biochemistry, North Carolina Central University , Durham , NC 27707 North Carolina

3. Department of Environmental Studies, University of Guyana, Turkeyen Campus , Greater Georgetown , Guyana South America

Abstract

Abstract Biopesticides are generally considered a safer and more environmentally friendly alternative to conventional pesticides. Plant metabolites display a range of pest specific activity ranging from antimicrobial to larvicidal and nematocidal. We herein describe the evaluation of a Guyanese collection of Vismia guianensis (Clusiaceae) for anthelmintic activity. The bioassay-guided evaluation of the hexane extract yielded the new prenylated benzophenone 8,9-epoxyvismiaphenone F (1). The final structures were elucidated based on spectral analysis and comparison to the known metabolite. To evaluate the anthelmintic efficacy of these compounds, Caenorhabditis elegans were exposed to the compounds via a ring assay model. Post-exposure, the numbers of live C. elegans in the compound (middle), bacteria ring were recorded for 3 d, as well as the total number of live worms for each plate. Compound 1 reduced C. elegans’ overall growth and reproduction, suggesting that these prenylated benzophenones may hold some promise as natural pesticides.

Publisher

Walter de Gruyter GmbH

Link

https://www.sciendo.com/pdf/10.2478/jofnem-2022-0054

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