Follicular renewal and stemness potency of follicular cells depended of telomerase activity and TERT expression

Follicular renewal and stemness potency of follicular cells depended of telomerase activity and TERT expression – short review

Published:2022-03-01 Issue:1 Volume:10 Page:29-33
ISSN:2544-3577
Container-title:Medical Journal of Cell Biology
language:en
Short-container-title:

Author:

Zgórecka Wiktoria¹,Narenji Afsaneh Golkar²,Krajnik Kornelia³,Antosik Paweł⁴,Bukowska Dorota⁵,Grzesiak Małgorzata⁶,Prochazka Radek⁷,Mozdziak Paul²⁸,Skowroński Mariusz T.⁹,Kranc Wiesława¹

Affiliation:

1. Department of Anatomy , Poznan University of Medical Sciences , Poznań , Poland

2. Prestage Department of Poultry Science , North Carolina State University , Raleigh , NC, USA

3. Department of Animal Physiology and Neurobiology , Faculty of Biological and Veterinary Sciences , Nicolaus Copernicus University in Torun , Toruń , Poland

4. Department of Veterinary Surgery, Institute of Veterinary Medicine , Nicolaus Copernicus University in Torun , Toruń , Poland

5. Department of Diagnostics and Clinical Sciences, Institute of Veterinary Medicine , Nicolaus Copernicus University in Torun , Toruń , Poland

6. Department of Endocrinology, Institute of Zoology and Biomedical Research , Jagiellonian University in Krakow , Kraków , Poland

7. Institute of Animal Physiology and Genetics, Czech Academy of Sciences , Liběchov , Czech Republic

8. Physiology Graduate Program , North Carolina State University , Raleigh , NC, USA

9. Department of Basic and Preclinical Sciences, Faculty of Biological and Veterinary Sciences , Nicolaus Copernicus University in Torun , Toruń , Poland

Abstract

Abstract Several hypotheses have been proposed, relating to the potential genesis of follicular cells in the ovarian niche. Reports using mice as an experimental model have suggested that the ovaries may contain stem cells that are likely involved in the formation of new follicles in adult reproductive life. Over recent years, various types of ovarian cells have been identified and described to confirm or disprove the existence of ovarian adult stem cells. Most research is focused on granulosa cells (GCs), which are essential for follicular development and maturation of female germ cells (oocytes). GCs exhibit the features of stem cells, such as expression of stem cell markers: OCT-4, Sox-2, Nanog as well as certain markers of mesenchymal stem cells, including CD29, CD44, CD90, CD105, CD117, and CD166. Another discovery in favor of the potential stemness of GCs is their ability to transdifferentiate towards other cell lines and high telomerase (TERT) activity in dividing compartments of the follicle during its maturation.

Publisher

Walter de Gruyter GmbH

Subject

Cell Biology,Molecular Biology

Link

https://www.sciendo.com/pdf/10.2478/acb-2022-0005

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