Mn(II), Fe(III) and Ni (II) Complexes of Mixed Citric acid - Sulphamethoxazole: Synthesis, Characterization and Antibacterial activity
Author:
Lawal Amudat1, Olowude Seyi1, Rajee Abdullahi O.1, Elaigwu Sunday E.1, Bamigboye Mercy O.2, Saadu Haizat O.1, Mamman Amos1, Babamale Halimat F.2, Yunus-Issa Muslimat T.3, Amolegbe Saliu A.4
Affiliation:
1. Department of Chemistry, Faculty of Physical Sciences , University of Ilorin , Ilorin , Nigeria 2. Department of Industrial Chemistry , University of Ilorin , P.M.B 1515 , Ilorin , Nigeria 3. School of Science, Federal College of Education , Osiele , Abeokuta , Nigeria 4. Department of Chemistry , Federal University of Agriculture , Abeokuta , Nigeria .
Abstract
Abstract
Three mixed ligand complexes of sulphamethoxazole and citric acid have been synthesized using Mn(II), Fe(III) and Ni(II) chlorides. The complexes were characterized by elemental analysis, melting point, conductivity test, magnetic measurement, UV-Visible and infrared spectroscopy. The infrared spectra data revealed that the ligands act as bidentate, in which citric acid coordinate through C=O of the carboxyl and oxygen of the hydroxyl groups, while sulphamethoxazole coordinates through nitrogen atom of the primary amine group and O=S=O of the sulphonyl group. The result of the elemental analysis was consistent with the proposed pattern for the complexes, while the melting point determination confirmed that the synthesized compounds were pure. Antibacterial activity of metal complexes were screening against five strain bacteria microorganism of g(+)Pseudomonas aeruginosa, Eschericia coli, g(+)Klebsiella pneumonia, g(+)Staphylococcus aureus and g(+)Candida using Muller Hinton diffusion method. The result showed that the overall zone of inhibition against bacterial isolate follows an increasing order of priority Fe(III)˃ Ni(II)˃ Mn(II) complexes.
Publisher
Walter de Gruyter GmbH
Reference16 articles.
1. Ajibade, P. A. (2008). Metal complexes in the management of parasitic diseases: in vitro antiprotozoal studies of metal complexes of some antimalarial drugs. Current Science. 95(12), 1673. 2. Chu, D. T., Plattner, J. J., & Katz, L. (1996). New directions in antibacterial research. Journal of medicinal chemistry. 39(20), 3853-3874. 3. Collins, C. H., Lynes, P. M., & Grange, J. M. (1995). Microbiological Methods. (7thEdn.) Butterwort. 4. Cotton, F. A., Wilkinson, G., Murillo, C. A., & Bochmann, M. (1999). Advanced inorganic chemistry. John Wiley and Sons, Inc.. 5. Deacon, G. B., & Phillips, R. J. (1980). Relationships between the carbon-oxygen stretching frequencies of carboxylato complexes and the type of carboxylate coordination. Coordination chemistry reviews. 33(3), 227-250.
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