Current state of umbilical cord stem cells in humans-Reference-Cited by-同舟云学术

Current state of umbilical cord stem cells in humans

Published:2019-10-01 Issue:3 Volume:7 Page:86-89
ISSN:2544-3577
Container-title:Medical Journal of Cell Biology
language:en
Short-container-title:

Author:

Borys-Wójcik Sylwia¹,Moncrieff Lisa²,Kempisty Bartosz¹³⁴,Dyszkiewicz-Konwińska Marta¹⁵

Affiliation:

1. Department of Anatomy, Poznań University of Medical Sciences , Poznań , Poland

2. School of Medicine, Medical Sciences and Nutrition, University of Aberdeen , Aberdeen , United Kingdom

3. Department of Histology and Embryology, Poznań University of Medical Sciences , Poznań , Poland

4. Department of Obstetrics and Gynecology, University Hospital and Masaryk University , Brno Czech Republic

5. Department of Biomaterials and Experimental Dentistry, Poznan University of Medical Sciences , Poznań , Poland

Abstract

Abstract The umbilical cord is an unlimited source of mesenchymal stem cells (MSC) and hematopoietic stem cells (HSC). MSC obtained from the umbilical cord can be differentiated into different types of mesodermal cells, e.g. chondrocytes, osteocytes, adipocytes, and myocytes. It is also worth mentioning that there are reports of MSC differentiation into endo and ectodermal cells. The immunosuppressive properties of MSCs can protect against graft versus host disease as well as prevent rejection after transplantation. Umbilical cord stem cells can be frozen and then stored in liquid nitrogen for many years. In this work, we focused on the use of preclinical and clinical umbilical cord stem cells in disease entities such as type I diabetes, chronic renal failure, and multiple sclerosis. Furthermore, the anti-cancer properties of Wharton’s jelly cells are described. Running title: Umbilical cord stem cells in humans

Publisher

Walter de Gruyter GmbH

Subject

Cell Biology,Molecular Biology

Link

https://www.sciendo.com/pdf/10.2478/acb-2019-0011

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