Internal Regularity of D-Glyceraldehide-3-Phosphate Dehydrogenase Genes and Proteins

Abstract

Internal Regularity ofD-Glyceraldehide-3-Phosphate Dehydrogenase Genes and ProteinsData of analysis of some GAPDH family gene exon and intron length (nt) and intron position coordinates as a sum of preceeding exon dimensions) and their internal regularity were analyzed based on a working hypothesis that primieval gene precursors were regular and periodic polynucleotides formed from oligonucleotides identical in size. The number of nucleotides in a gene repeat unit was denoted by a specific term - gene quantum and symbolQ. The following genes were analyzed: the chicken GAPDH (12 exons/11 introns) gene, theChlamidomonas reinhardtii gapA(6 exons, 5 introns) andgapC(7 exons, 6 introns) genes. The determined value ofQfor all these genes was identical and constituted 9 nucleotides. The sum total of all above-mentioned gene intron dimensions, independently of intron number in a gene, could be precisely quantized - expressed as a product of a gene quantum and a whole number, e.g., for the chicken GAPDH 1628 nt = 9 nt x 292,0. The garden peaPissum sativumfragment (amino acids 167-219) was partially regular (the repeat unit size 9 aa) and showed translational symmetry. The obtained data supported the model that the precursors of the modern genes were originated by nucleotide multiplication reactions.