Gastroprotective effect of the flavonoid fustin isolated from Cotinus coggygria heartwood in a rat model of indomethacin-induced gastric ulceration
Author:
Georgieva Antoaneta1, Pavlov Danail2, Tzaneva Maria3, Novakovic Miroslav4, Tesevic Vele5, Reyzov Mehmed1, Eftimov Miroslav1, Todorova Milena1, Nikolova Miglena2, Stefanova Nadezhda3, Valcheva-Kuzmanova Stefka1
Affiliation:
1. 1 Department of Pharmacology and Clinical Pharmacology and Therapeutics, Faculty of Medicine , Medical University “Prof. Dr. Paraskev Stoyanov” , Marin Drinov 55, 9002 Varna , Bulgaria 2. 2 Department of Biochemistry, Molecular Medicine and Nutrigenomics , Faculty of Pharmacy, Medical University “Prof. Dr. Paraskev Stoyanov” , 84B Tzar Osvoboditel Blvd., 9002 Varna , Bulgaria 3. 3 Department of General and Clinical Pathology, Forensic Medicine and Deontology, Faculty of Medicine , Medical University “Prof. Dr. Paraskev Stoyanov” , University hospital “St. Marina”, 1 Hristo Smirnenski Blvd, 9010 Varna , Bulgaria 4. 4 National Institute, Institute of Chemistry , Technology and Metallurgy, University of Belgrade , Njegoševa 12, 11000 Belgrade , Serbia 5. 5 Faculty of Chemistry , University of Belgrade , Studentski trg 12-16, 11158 , Belgrade , Serbia
Abstract
Abstract
Gastric ulcer is a common health issue. Cotinus coggygria heartwood extracts rich in the flavonoids fustin and sulfuretin have shown protective effects in a rat model of indomethacin-induced gastric ulceration. Fustin itself has been protective in a rat model of ethanol-induced gastric ulcer. In the present study we aimed to reveal the effect of the flavonoid fustin isolated from Cotinus coggygria heartwood in a rat model of indomethacin-induced gastric ulceration.
Fustin was isolated from Cotinus coggygria heartwood and purified. The experiment was performed on 30 male Wistar rats allocated to three groups – Control, Indo and F10. F10 group was pretreated with fustin (10 mg/kg b.w. for 7 days). Rats were sacrificed and macroscopic, histopathological and immunohistochemical investigations of the stomachs were performed.
Indomethacin caused severe mucosal damage, proven by the macroscopic, microscopic and immunohistochemical gastric mucosa investigation. Fustin pretreatment slightly reduced the macroscopic indices for gastric damage (ulcer number, area, score and index), and significantly alleviated the severity of the microscopic indices (mucosal erosions, necrosis, hemorrhages and inflammation). In fustin-pretreated rats, the expression of NF-κB was reduced in comparison with indomethacin-treated animals.
In conclusion, fustin exerted a gastroprotective action in an indomethacin-induced gastric ulceration model, probably due to its anti-inflammatory activity.
Publisher
Walter de Gruyter GmbH
Subject
Materials Science (miscellaneous)
Reference19 articles.
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