Affiliation:
1. University of Zagreb , Faculty of Pharmacy and Biochemistry 10000 Zagreb , Croatia
Abstract
Abstract
Cancer presents one of the leading causes of death in the world. Current treatment includes the administration of one or more anticancer drugs, commonly known as chemotherapy. The biggest issue concerning the chemotherapeutics is their toxicity on normal cells and persisting side effects. One approach to the issue is chemoprevention and the other one is the discovery of more effective drugs or drug combinations, including combinations with polyphenols. Olive oil polyphenols (OOPs), especially hydroxytyrosol (HTyr), tyrosol (Tyr) and their derivatives oleuropein (Ole), oleacein and oleocanthal (Oc) express anticancer activity on different cancer models. Recent studies report that phenolic extract of virgin olive oil may be more effective than the individual phenolic compounds. Also, there is a growing body of evidence about the combined treatment of OOPs with various anticancer drugs, such as cisplatin, tamoxifen, doxorubicin and others. These novel approaches may present an advanced strategy in the prevention and treatment of cancer.
Subject
Pharmaceutical Science,Pharmacology,General Medicine
Reference119 articles.
1. 1. WHO Cancer, WHO.; Accessed May 21, 2019, from http://www.who.int/cancer/en/
2. 2. What Is Cancer?, National Cancer Institute; Accessed May 21, 2019, from https://www.cancer.gov/about-cancer/understanding/what-is-cancer
3. 3. N. A. Lobo, Y. Shimono, D. Qian and M. F. Clarke, The biology of cancer stem cells, Annu. Rev. Cell Dev. Biol.23 (2007) 675–699; https://doi.org/10.1146/annurev.cellbio.22.010305.10415410.1146/annurev.cellbio.22.010305.104154
4. 4. F. Bray, J. Ferlay, I. Soerjomataram, R. L. Siegel, L. A. Torre and A. Jemal, Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries, CA-Cancer J. Clin.68 (2018) 394–424; https://doi.org/10.3322/caac.2149210.3322/caac.21492
5. 5. T. Nabekura, Overcoming multidrug resistance in human cancer cells by natural compounds, Toxins2 (2010) 1207–1224; https://doi.org/10.3390/toxins206120710.3390/toxins2061207
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