Carbon nanotubes with controlled length – preparation, characterization and their cytocompatibility effects
Author:
Cendrowski Krzysztof1, Jedrzejczak-Silicka Magdalena2
Affiliation:
1. West Pomeranian University of Technology Szczecin , Nanomaterials Physicochemistry Department, Faculty of Technology and Chemical Engineering , Piastow Avenue 45, Szczecin 70-311 , Poland 2. West Pomeranian University of Technology Szczecin , Laboratory of Molecular Cytogenetic , Klemensa Janickiego 29, Szczecin 71-270 , Poland
Abstract
Abstract
Multiwalled carbon nanotubes (MWCNTs) have attracted huge attention due to their multifunctionality. Their unique properties allows for covalent and noncovalent modifications. The most simple method for functionalization of carbon nanotubes is their decoration with the oxygen containing moieties which can be further simultaneously functionalized for design of new class carriers for targeting and imaging. Here, we present methodology for chopping nanotubes, characterization of MWCNTs, the effect of size on the biocompatibility in culture of L929 mouse fibroblasts using WST-1, LDH and apoptosis assays. The analysis provides the optimal carbon nanotubes length and concentration which can be used for functionalization in order to minimize the effect of the secondary agglomeration when interacting with cells.
Publisher
Walter de Gruyter GmbH
Subject
General Chemical Engineering,General Chemistry,Biotechnology
Reference38 articles.
1. 1. Iijima, S. (1991). Helical microtubules of graphitic carbon. Nature, 354, 56–58. DOI: 10.1038/354056a0.10.1038/354056a0 2. 2. Donaldson, K., Aitken, R., Tran, L., Stone, V., Duffin, R., Forrest, G. & Alexander, A. (2006). Carbon nanotubes: a review of their properties in relation to pulmonary toxicology and workplace safety. Toxicol. Sci. 92, 5–22. DOI: 10.1093/toxsci/kfj130.10.1093/toxsci/kfj130 3. 3. Chen, X., Chen, H., Tripisciano, C., Jedrzejewska, A., Rümmeli, H.M., Klingeler, R., Chu, P.K. & Borowiak-Palen, E. (2011). Carbon-nanotube-based stimuli-responsive controlled-release system. Chem. Eur. J. 17, 4454–4459. DOI: 10.1002/chem.201003355.10.1002/chem.201003355 4. 4. Kumar, A.P., Hul, Y., Yamamoto, Y., Hoe, N.B., Wie, T.S., Mu, D., Sun, Y., Joo, L.S., Dagher, R., Zielonka, L.M., Wang, D.Y., Lim, B., Chow, V. T., Crum, C. P., Xian, W. & McKeon, F. (2011). Distal airway s tem cells yield alveoli in v itro a nd during lung regeneration following H1N1 influenza infection. Cell, 147, 525–538. DOI: 10.1016/j.cell.2011.10.001.10.1016/j.cell.2011.10.001 5. 5. Meng, L., Zhang, X., Lu, Q., Fei, Z. & Dyson, P.J. (2012). Single walled carbon nanotubes as drug delivery vehicles: targeting doxorubicin to tumors. Biomaterials, 33, 1689–1698. DOI: 10.1016/j.biomaterials.2011.11.004.10.1016/j.biomaterials.2011.11.004
Cited by
2 articles.
订阅此论文施引文献
订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献
|
|