Anticancer activity of some new series of 2-(substituted)amino-1,3-thiazole derivatives-Reference-Cited by-同舟云学术

Anticancer activity of some new series of 2-(substituted)amino-1,3-thiazole derivatives

Published:2019-09-01 Issue:3 Volume:21 Page:19-25
ISSN:1899-4741
Container-title:Polish Journal of Chemical Technology
language:en
Short-container-title:

Author:

Bakare Safyah B.¹

Affiliation:

1. Faculty of Education , Shaqra University , Al Muzahimiyah, Shaqra , Riyadh Province, P.O. Box 90, Zip Code 11921 , Kingdom Saudi Arabia

Abstract

Abstract A series of thiazole derivatives were synthesized and structurally elucidated by IR, 1H NMR, 13C NMR, mass and elemental analyses. The prepared compounds were screened for their cytotoxic activity against Leukemia HL-60 cell line. Compound 4b was considered as the most promising antitumor candidate among the tested compounds. Mechanism of action of compound 4b evaluated by flow cytometric assay revealed cell cycle arrest at G2/M phase and pre-G1 apoptosis. The ratio of apoptosis was also determined. Moreover, compound 4b increased the concentration of caspase 3 by 4 fold more than untreated control.

Publisher

Walter de Gruyter GmbH

Subject

General Chemical Engineering,General Chemistry,Biotechnology

Link

https://www.sciendo.com/pdf/10.2478/pjct-2019-0025

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