Design of Microfluidic Device and Measurements of MPWM for Single Cell /Particle Manipulation

Author:

Ardeleanu Mihǎiţǎ Nicolae12,Mihai Simona3,Vidu Ruxandra4,Diaconu Emil Mihai5,Popescu Ileana Nicoleta1

Affiliation:

1. Faculty of Materials Engineering and Mechanics , Valahia University of Targoviste , 13 Aleea Sinaia Street, Targoviste , Romania

2. S.C. Celteh Mezotronic S.R.L. , Calea Câmpulung Street, No. 6A, Targoviste , Romania

3. The Scientific and Technological Multidisciplinary Research Institute (ICSTM-UVT) , Valahia University of Targoviste , Romania

4. California Solar Energy Collaborative , University of California , Davis, 1, Shields Ave, Davis , USA

5. Faculty of Electrical Engineering, Electronics and Information Technology , Valahia University of Targoviste , 13 Aleea Sinaia Street, Targoviste , Romania

Abstract

Abstract A microfluidic device designated for measurement of fluidic flows with different viscosity, necessary within trapping/realising of cells/particles system has been developed. We use a new concept as Microfluidic Pulse Width Modulation (MPWM) for controlling transport of a single cell/particle. The image processing helped the nano-hydraulic volumes/flow rates measurement, through tracking inovative methods with the purpose to build a flow sensor. The device open an unique opportunitie for single cell study with applications in biomedical devices, tools for biochemistry or analytical systems.

Publisher

Walter de Gruyter GmbH

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