Author:
Debnath Monojit,Doyle Karen,Langan Camilla,McDonald Colm,Leonard Brian,Cannon Dara
Abstract
AbstractPsychiatric disorders are common and complex and their precise biological underpinnings remain elusive. Multiple epidemiological, molecular, genetic and gene expression studies suggest that immune system dysfunction may contribute to the risk for developing psychiatric disorders including schizophrenia, bipolar disorder, and major depressive disorder. However, the precise mechanisms by which inflammation-related events confer such risk are unclear. In this review, we examine the peripheral and central evidence for inflammation in psychiatric disorders and the potential molecular mechanisms implicated including inhibition of neurogenesis, apoptosis, the HPA-axis, the role of brain-derived neurotrophic factor and the interplay between the glutamatergic, dopaminergic and serotonergic neurotransmitter systems.
Reference259 articles.
1. Kendler K.S., Prescott C.A., Myers J., Neale M.C., The structure of genetic and environmental risk factors for common psychiatric and substance use disorders in men and women, Arch. Gen. Psychiatry, 2003, 60, 929–937
2. Muller N., Schwarz M.J., Immune system and schizophrenia, Curr. Immunol. Rev., 2010, 6, 213–220
3. Stefansson H., Ophoff R.A., Steinberg S., Andreassen O.A., Cichon S., Rujescu D., et al., Common variants conferring risk of schizophrenia, Nature, 460, 744–747
4. Shi J., Levinson D.F., Duan J., Sanders A.R. Zheng Y., Peer I., et al., Common variants on chromosome 6p22.1 are associated with schizophrenia, Nature, 2009, 460, 753–757
5. Williams H.J., Craddock N., Russo G., Hamshere M., Moskvina V., Dwyer R., et al., Most genome wide significant susceptibility loci for schizophrenia and bipolar disorder reported to date cross traditional diagnostic boundaries, Hum. Mol. Genet., 2011, 20, 387–391
Cited by
23 articles.
订阅此论文施引文献
订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献