α-synuclein regulation of dopamine transporter
Author:
Butler Brittany,Saha Kaustuv,Khoshbouei Habibeh
Abstract
AbstractThe development of effective therapeutic interventions for neurodegeneration requires a better understanding of the early events that precede neuronal loss. Recent work in various disease models has begun to emphasize the significance of presynaptic dysfunction as an early event that occurs before manifestation of neurological disorders. Dysregulation of dopamine (DA) homeostasis is implicated in neurodegenerative diseases, drug addiction, and neuropsychiatric disorders. The neuronal plasma membrane dopamine transporter (DAT) is essential for the maintenance of DA homeostasis in the brain. α-synuclein is a 140-amino acid protein that forms a stable complex with DAT and is linked to the pathogenesis of neurodegenerative disease. In this review we will examine the prevailing hypotheses for α-synuclein-regulation of DAT biology.
Publisher
Walter de Gruyter GmbH
Subject
General Neuroscience
Reference113 articles.
1. Abramov, E., Dolev, I., Fogel, H., Ciccotosto, G. D., Ruff, E., and Slutsky, I. (2009) Amyloid-beta as a positive endogenous regulator of release probability at hippocampal synapses, Nat Neurosci 12, 1567–1576. 2. Gray, B. C., Siskova, Z., Perry, V. H., and O’Connor, V. (2009) Selective presynaptic degeneration in the synaptopathy associated with ME7-induced hippocampal pathology, Neurobiol Dis 35, 63–74. 3. Zhang, C., Wu, B., Beglopoulos, V., Wines-Samuelson, M., Zhang, D., Dragatsis, I., Sudhof, T. C., and Shen, J. (2009) Presenilins are essential for regulating neurotransmitter release, Nature 460, 632–636. 4. Nemani, V. M., Lu, W., Berge, V., Nakamura, K., Onoa, B., Lee, M. K., Chaudhry, F. A., Nicoll, R. A., and Edwards, R. H. (2010) Increased expression of alpha-synuclein reduces neurotransmitter release by inhibiting synaptic vesicle reclustering after endocytosis, Neuron 65, 66–79. 5. Chandra, S., Fornai, F., Kwon, H. B., Yazdani, U., Atasoy, D., Liu, X., Hammer, R. E., Battaglia, G., German, D. C., Castillo, P. E., and Sudhof, T. C. (2004) Double-knockout mice for alpha- and beta-synucleins: effect on synaptic functions, Proc Natl Acad Sci U S A 101, 14966–14971.
Cited by
5 articles.
订阅此论文施引文献
订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献
|
|