Role of IL-33/ST2 Axis in Chronic Inflammatory Neurological Disorderss-Reference-Cited by-同舟云学术

Role of IL-33/ST2 Axis in Chronic Inflammatory Neurological Disorderss

Published:2021-12-08 Issue:0 Volume:0 Page:
ISSN:2335-075X
Container-title:Serbian Journal of Experimental and Clinical Research
language:en
Short-container-title:

Author:

Dimitrijevic Jelena¹²,Arsenijevic Aleksandar¹,Milovanovic Marija¹,Stojanovic Bojana¹³,Arsenijevic Dragana¹⁴,Milovanovic Jelena¹⁵,Arsenijevic Nebojsa¹

Affiliation:

1. University of Kragujevac, Faculty of Medical Sciences , Center for Molecular Medicine and Stem Cell Research , Kragujevac , Serbia

2. University of Kragujevac, Faculty of Medical Sciences , Department of Medical statistics and informatics , Kragujevac , Serbia

3. University of Kragujevac, Faculty of Medical Sciences , Department of Pathophysiology , Kragujevac , Serbia

4. University of Kragujevac, Faculty of Medical Sciences , Department of Pharmacy , Kragujevac , Serbia

5. University of Kragujevac, Faculty of Medical Sciences , Department of Histology and Embriology , Kragujevac , Serbia

Abstract

Abstract Interleukin-33 (IL-33) is a member of IL-1 family of cytokines, produced constitutively by fibroblasts, endothelial cells, and epithelial cells. IL-33 can be released passively from cells during tissue damage and cell necrosis, suggesting that it may act as an alarmin. Function of IL-33 is mediated by its interaction with ST2 molecule that is expressed on many immune cells: Th2 lymphocytes, NK, NKT and mast cells, monocytes, dendritic cells and granulocytes. IL-33/ST2 pathway plays, often dual, roles in different physiological and inflammatory processes, mediating both, pathological immune responses and tissue repair. Expression of IL-33 in the central nervous system (CNS) is significantly enhanced during various pathological processes, indicating its important role in the pathogenesis of neurological inflammatory and degenerative diseases. In this review the biological features, expression of IL-33 and its ligand ST2 in CNS, and the role of IL- 33/ST2 pathway in development of Alzheimer’s disease and multiple sclerosis are discussed.

Publisher

Walter de Gruyter GmbH

Subject

General Medicine

Link

https://www.sciendo.com/pdf/10.2478/sjecr-2020-0038

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