Investigation of thrombogenic risk factors in young adult male sportsmen

Abstract

Abstract The study aimed to check the impact of sportsmen’s physical activity on blood coagulation processes and myocardial micro injuries in young adult male sportsmen. Comparing the results of athletes before and after 6 months of the training season, a statistically significant increase in the following parameters: PT (12.03±0.76 vs. 13.51±0.72 s; p<0.01), INR (1.03±0.07 vs. 1.14±0.06; p<0.01), APPT (28.73±3.27 vs. 33.31±5.63 s; p<0.01) and TT (20.62±0.97 vs. 22.49 ±1.41 s; p<0.01) was observed. Analyzing the results between the control group and the study group before training, the following changes were observed: APTT (35.26±6.74 vs. 28.73±3.27 s; p<0.01), HGMCR (750.17±59.23 vs. 569.38±51.24 ng/L; p <0.01) and L-FABP (329.16±92.04 vs. 151.80±70.10 ng/L; p=0.02) and an increase in H-FABP level (2.75±1.32 vs. 4.14±1.30 ng/mL; p<0.01). Comparing the values between the control group and the study group, but after training, an increase in the value for PT (12.88±1.41 vs. 13.51±0.72 s; p = 0.02), INR (1.09±0.13 vs. 1.14±0.06; p=0.02), TT (20.64±1.43 vs. 22.49±1.41 s; p<0.01) and H-FABP (2.75±1.32 vs. 3.94±1.47 ng/L; p<0.01) and decrease in HGMCR activity (750.17±59.23 vs. 581.47±51.25 ng/L; p<0.01) were observed. There was also a strong positive correlation between HGMCR and H-FABP (r = 0.77) and a strong negative correlation between TT and Fb (r = -0.808) and between TT and APTT (r = -0.424). Summarizing our study, we confirm that physical activity in sportsmen, especially overtraining, may have an impact on blood coagulation processes and may also lead to microdamage of the heart muscle.