Detecting Sex-Biased Gene Flow in African-americans Through the Analysis of Intra- and Inter-Population Variation at Mitochondrial DNA and Y- Chromosome Microsatellites

Author:

Battaggia C.,Anagnostou P.,Bosch I.,Brisighelli F.,Destro-Bisol G.,Capocasa M.

Abstract

ABSTRACT This study reports on variations at the mitochondrial DNA (mtDNA) hypervariable region 1 (HVR-1) and at seven Y-chromosome microsatellites in an African-American population sample from Chicago, IL, USA. Our results support the hypothesis that the population studied had undergone a European malebiased gene flow. We show that comparisons of intraand inter-population diversity parameters between African-Americans, Europeans and Africans may help detect sex-biased gene flow, providing a complement to quantitative methods to estimate genetic admixture.

Publisher

Walter de Gruyter GmbH

Subject

Genetics (clinical),Genetics

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