One step synthesis of Diflunisal using a Pd-diamine complex-Reference-Cited by-同舟云学术

One step synthesis of Diflunisal using a Pd-diamine complex

Published:2009-12-01 Issue:4 Volume:7 Page:818-826
ISSN:2391-5420
Container-title:Open Chemistry
language:
Short-container-title:

Author:

Kylmälä Tuula¹,Tois Jan¹,Xu Youjun²,Franzén Robert¹

Affiliation:

1. 1Department of Chemistry and Bioengineering, Laboratory of Chemistry, Tampere University of Technology, Tampere, FIN-33720, Finland

2. 2School of Pharmaceutical Engineering, Shenyang Pharmaceutical University, Shenyang, 110016, China

Abstract

AbstractDiflunisal and Felbinac, two FDA-approved NSAIDs and other biphenyl carboxylic acids were prepared in one step by a simple and clean Suzuki cross-coupling reaction using an easily synthesized, air and moisture stable, palladium-diamine complex. The yield (93%) for the one-step preparation of Diflunisal is the best reported without using a glovebox and a phoshine-based catalyst.

Publisher

Walter de Gruyter GmbH

Subject

Materials Chemistry,General Chemistry

Link

http://link.springer.com/content/pdf/10.2478/s11532-009-0068-1.pdf

Reference51 articles.

1. http dx org;Kania;Chemosphere,2004

2. http dx org;Badone;Org Chem,1997

3. http dx org;Liu;Tetrahedron Lett,2005

4. Fast, easy, clean chemistry by using water as a solvent and microwave heating: the Suzuki coupling as an illustration

5. http dx org;Feliu;J Pept Res Therapeut,2005

Cited by 14 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. Kinetic Aspects of Suzuki Cross-Coupling Using Ligandless Pd Nanoparticles Embedded in Aromatic Polymeric Matrix;Processes;2023-03-15

2. Suzuki–Miyaura cross-coupling reaction assisted by palladium nanoparticles-decorated zeolite 13X nanocomposite: a greener approach;Research on Chemical Intermediates;2022-01-10

3. Waste biomass-derived carbon-supported palladium-based catalyst for cross-coupling reactions and energy storage applications;Applied Surface Science;2021-12

4. Water-Dispersible Pd–N-Heterocyclic Carbene Complex Immobilized on Magnetic Nanoparticles as a New Heterogeneous Catalyst for Fluoride-Free Hiyama, Suzuki–Miyaura and Cyanation Reactions in Aqueous Media;Catalysis Letters;2021-11-06

5. Sustainable Synthesis of Biaryls Using Silica Supported Ferrocene Appended N-Heterocyclic Carbene-Palladium Complex;Catalysis Letters;2021-01-02