Synthesis of Xenbucin using Suzuki reaction catalyzed by Pd/C in water-Reference-Cited by-同舟云学术

Synthesis of Xenbucin using Suzuki reaction catalyzed by Pd/C in water

Published:2008-09-01 Issue:3 Volume:6 Page:390-392
ISSN:2391-5420
Container-title:Open Chemistry
language:
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Author:

Kuuloja Noora¹,Kylmälä Tuula¹,Xu Youjun²,Franzén Robert¹

Affiliation:

1. 1Department of Chemistry and Bioengineering, Tampere University of Technology, 33101, Tampere, Finland

2. 2School of Pharmaceutical Engineering, Shenyang Pharmaceutical University, Shenyang, 110016, China

Abstract

AbstractXenbucin 1, an analgesic drug, was synthesized in 4 steps using two different routes. The biaryl fragment could successfully be produced via a Pd/C catalysed Suzuki coupling in water using sodium tetraphenylborate as a phenylation reagent. Overall yields of the routes were 36% and 59%, respectively.

Publisher

Walter de Gruyter GmbH

Subject

Materials Chemistry,General Chemistry

Link

http://link.springer.com/content/pdf/10.2478/s11532-008-0044-1.pdf

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