Determination of lipophilicity for antitumor acridinone derivatives supported by gradient high-performance liquid chromatography method-Reference-Cited by-同舟云学术

Determination of lipophilicity for antitumor acridinone derivatives supported by gradient high-performance liquid chromatography method

Published:2012-02-01 Issue:1 Volume:10 Page:216-223
ISSN:2391-5420
Container-title:Open Chemistry
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Author:

Koba Marcin¹,Belka Mariusz²,Ciesielski Tomasz³,Bączek Tomasz

Affiliation:

1. 1Collegium Medicum of Nicolaus Copernicus University

2. 2Medical University of Gdańsk

3. 3Norwegian University of Science and Technology

Abstract

AbstractThe lipophilicity values of selected acridinone (imidazoacridinone and triazoloacridinone) derivatives were measured by gradient reversed-phase high-performance liquid chromatography (RP-HPLC) using a C18 stationary phase with a water/acetonitrile mixture as a mobile phase. The retention times obtained served as input data and appropriate log kw values (i.e., the retention factor log kw extrapolated to 0% organic modifier) as an alternative to log P were calculated using the DryLab program. The relationships between the lipophilicity (log kw) and the chemical structure of the studied compounds, as well as correlation between experimentally determined lipophilicities (log kw) and log P data calculated using some commonly available software, are discussed.

Publisher

Walter de Gruyter GmbH

Subject

Materials Chemistry,General Chemistry

Link

http://link.springer.com/content/pdf/10.2478/s11532-011-0131-6.pdf

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