Chromatographic techniques in analysis of cyclooxygenase-2 inhibitors in drugs and biological samples

Author:

Starek Małgorzata1,Dąbrowska Monika1

Affiliation:

1. 1Department of Inorganic and Analytical Chemistry, Faculty of Pharmacy, Collegium Medicum, Jagiellonian University, 30-688, Kraków, Poland

Abstract

AbstractNon-steroidal anti-inflammatory drugs, as a therapeutic class, are among the most often used active pharmaceutical ingredients in heath care in the world. They are mostly available without prescription and often used for treatment of fever and pain. An extensive research of the literature published in analytical and pharmaceutical chemistry journals has been conducted and the chromatographic methods which were used for the purity, stability and pharmacokinetic studies of the cyclooxygenase-2 inhibitors, in formulations and biological materials have been reviewed. The methodology for the analysis of selected drugs is very well documented and many examples are available in the literature. The common use of chromatographic techniques with various detection attachments provide possibility for monitoring of drugs in therapy.

Publisher

Walter de Gruyter GmbH

Subject

Materials Chemistry,General Chemistry

Reference76 articles.

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2. http dx org;Starek;Talanta,2011

3. http dx org;Bebawy;Pharm Biomed Anal,2002

4. http dx org;Zhang;Drug Metab Disp,2003

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