Synthesis of a series of vicinal diamines with potential biological activity-Reference-Cited by-同舟云学术

Synthesis of a series of vicinal diamines with potential biological activity

Published:2004-12-01 Issue:4 Volume:2 Page:686-695
ISSN:2391-5420
Container-title:Open Chemistry
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Author:

Kurteva Vanya¹,Lyapova Maria¹

Affiliation:

1. 1Institute of Organic Chemistry, Bulgarian Academy of Sciences, Acad. G. Bonchev str., bl.9, 1113, Sofia, Bulgaria

Abstract

AbstractA broad range of vicinal diamines based on styrene oxide are synthesisedvia mixtures of regioisomeric amino alcohols. The ring opening of the intermediate aziridinium ions by primary amines proceeds with high regioselectivity, leading to the target diamines as single regioisomers for all reaction series. The compounds are of potential biological interest as ligands for cisplatin analogues. Anticancer activity tests of both groups of compounds are in progress.

Publisher

Walter de Gruyter GmbH

Subject

Materials Chemistry,General Chemistry

Link

http://link.springer.com/content/pdf/10.2478/BF02482731.pdf

Reference4 articles.

1. Table continue Analytical and NMR data δ referenced to TMS as an internal standard in Hz ) of the skeleton nuclei of diamines Yield Formula Found;CDCl;Central European Journal of Chemistry Analysis,2004

2. cited therein Synthesis and Application of Chiral Nonracemic Lithium Amide Bases in Enantioselective Deprotonation of Epoxides Relative Formula a ratio Found;Bhuniya;Design Org Chem Central European Journal of Chemistry Analysis,1996

3. a Determined as mixtures of regioisomers Table Relative ratios ( as determined by and analytical and NMR data δ referenced to TMS as an internal standard in Hz ) of the skeleton nuclei of amino alcohols and Yield Formula Found oil;CDCl;Central European Journal of Chemistry Analysis,2004

4. Table Analytical and NMR data δ referenced to TMS as an internal standard in Hz ) of the skeleton nuclei of diamines Yield Formula Found;CDCl;Central European Journal of Chemistry Analysis,2004

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