Affiliation:
1. Department of Public Health, School of Basic Medical Science , Putian University , Putian , Fujian , China
2. Key Laboratory of Translational Tumor Medicine in Fujian Province , School of Basic Medical Science , Putian University , Putian , Fujian , China
Abstract
Abstract
Background
Inflammatory bowel disease (IBD) is a condition with an unclear genetic basis. Fucosyltransferase 3 (FUT3) could potentially be linked to IBD susceptibility.
Objective
To investigate the association between FUT3 gene polymorphisms and IBD.
Methods
Following the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) 2020 checklist and Population, Intervention, Comparison, Outcomes, and Study (PICOS) guidelines, case-control studies published until April 30, 2020 was searched. Two independent reviewers conducted screening, data extraction, and quality assessment using the Newcastle-Ottawa Scale. Meta-analysis, sensitivity analysis, and Egger tests were performed using RevMan and Stata12.0.
Results
The review included 5 articles and 12 case-control studies involving 1712 IBD patients and 1903 controls. The meta-analysis revealed the following combined odds ratios [95% confidence intervals]: rs3745635 genotype (GA+AA vs GG) 0.84 (0.72–0.97), (GG+GA vs AA) 1.93 (1.23–3.05), (GG vs AA) 2.38 (1.52–3.74), (A vs G) 0.84 (0.73–0.96); rs3894326 genotype (TA+AA vs TT) 1.03 (0.87–1.23), (TT+TA vs AA) 1.19 (0.56–2.51), (TT vs AA) 1.19 (0.56–2.51), (A vs T) 1.02 (0.86–1.20); rs28362459 genotype (TG+GG vs TT) 0.98 (0.85–1.12), (TT+TG vs GG) 1.20 (0.90–1.61), (TT vs GG) 1.21 (0.90–1.62), (G vs T) 0.96 (0.86–1.07). Sensitivity analysis indicated the stability of the results, and Egger analysis showed no significant publication bias.
Conclusions
The rs3745635 gene polymorphism may be associated with IBD susceptibility, whereas the rs3894326 and rs28362459 gene polymorphisms may not be associated with IBD.
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