Modulation of TLR2 and TLR4 in macrophages following Trichinella spiralis infection
Author:
Han C.1, Xu J.1, Liu Ch.1, Li X.1, Zhai P.1, Hashan A.2, Song M.1
Affiliation:
1. College of Veterinary Medicine , Northeast Agricultural University , Harbin , Heilongjiang, 150030 , PR China 2. Tiemaike Animal Husbandry and Veterinary station , Fuyun , Xinjiang 836302 , PR China
Abstract
Summary
Parasitic helminthes can suppress and/or regulate the host immune response to allow long-term survival and chronic infection where toll-like receptors (TLRs) expressed on macrophages play essential roles in response to parasitic infection. Semi-quantitative PCR and flow cytometry studies about the modulation of TLRs and cytokine profiles in macrophages following T. spiralis infection were performed. TLRs, MyD88 and NF-κB were up-regulated by T. spiralis infection and essential to the parasite life cycles. Cytokines profiles (IL-6, IL-10, IL-12, TNF-α) were modulated during T. spiralis infection. Results suggest that T. spiralis infection may regulate the expression of TLR4 on macrophages and TLR4/MyD88/NF-κB signaling pathways. This study provides further insights into the mechanisms of TLR-mediated post-inflammatory response during T. spiralis infection.
Publisher
Walter de Gruyter GmbH
Subject
Animal Science and Zoology,Parasitology
Reference33 articles.
1. Aranzamendi, C., de Bruin, A., Kuiper, R., Boog, C.J., van Eden, W., Rutten, V., Pinelli, E. (2013): Protection against allergic airway inflammation during the chronic and acute phases of Trichinella spiralis infection. Clin. Exp. Allergy, 43(1): 103 – 115. DOI: 10.1111/cea.1204210.1111/cea.12042 2. Aranzamendi, C., Fransen, F., Langelaar, M., Franssen, F., van der Ley, P., van Putten, J.P., Rutten, V., Pinelli, E. (2012): Trichinella spiralis-secreted products modulate DC functionality and expand regulatory T cells in vitro. Parasite Immunol., 34(4): 210 – 223. DOI: 10.1111/j.1365-3024.2012.01353.x10.1111/j.1365-3024.2012.01353.x 3. Bai, X., Wu, X., Wang, X., Guan, Z., Gao, F., Yu, J., Yu, L., Tang, B., Liu, X., Song, Y., Wang, X., Radu, B., Boireau, P., Wang, F., Liu, M. (2012): Regulation of cytokine expression in murine macrophages stimulated by excretory/secretory products from Trichinella spiralis in vitro. Mol. Cell. Biochem., 360(1 – 2): 79 – 88. DOI: 10.1007/s11010-011-1046-410.1007/s11010-011-1046-4 4. Beiting, D.P., Gagliardo, L.F., Hesse, M., Bliss, S.K., Meskill, D., Appleton, J.A. (2007): Coordinated control of immunity to muscle stage Trichinella spiralis by IL-10, regulatory T cells, and TGF-beta. J. Immunol., 178(2): 1039 – 104710.4049/jimmunol.178.2.1039 5. Blum, L.K., Mohanan, S., Fabre, M.V., Yafawi, R.E., Appleton, J.A. (2013): Intestinal infection with Trichinella spiralis induces distinct, regional immune responses. Vet. Parasitol., 194(2 – 4): 101 – 105. DOI: 10.1016/j.vetpar.2013.01.03010.1016/j.vetpar.2013.01.030
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