EUS-guided fine needle biopsy is able to provide diagnosis in rare osteoclast-like giant cells undifferentiated carcinoma of the pancreas: report of two cases-Reference-Cited by-同舟云学术

EUS-guided fine needle biopsy is able to provide diagnosis in rare osteoclast-like giant cells undifferentiated carcinoma of the pancreas: report of two cases

Published:2023-05-08 Issue:2 Volume:61 Page:116-124
ISSN:2501-062X
Container-title:Romanian Journal of Internal Medicine
language:en
Short-container-title:

Author:

Pop Ruxandra Mihaela¹²,Diaconu Claudia Irina¹,Rimbaş Mihai¹²,Mateescu Radu Bogdan¹²,Rouhani Farid¹,Popp Cristiana³,Manfrin Erminia⁴,Crinò Stefano Francesco⁵,Cauni Victor⁶

Affiliation:

1. 1 Gastroenterology Department , Colentina Clinical Hospital , Bucharest, District 2, 19–21 Stefan cel Mare, 020125 , Romania

2. 2 Department of Internal Medicine , Carol Davila University of Medicine , Bucharest, District 5, 8 Eroii Sanitari , , Romania

3. 3 Department of Pathology , Colentina Clinical Hospital , Bucharest, District 2, 19–21 Stefan cel Mare, 020125 , Romania

4. 4 Department of Diagnostics and Public Health, Section of Pathology , University of Verona , 10 Piazzale Ludovico Antonio Scuro, 37124 , Verona , Italy

5. 5 Digestive Endoscopy Unit, The Pancreas Institute , G.B. Rossi University Hospital , 10 Piazzale LA Scuro, 37126 , Verona , Italy

6. 6 Urology Department , Colentina Clinical Hospital , Bucharest, District 2, 19–21 Stefan cel Mare street, 020125 , Romania

Abstract

Abstract Undifferentiated carcinoma of the pancreas with osteoclast-like giant cells (UC-OGC) is a rare subtype of pancreatic cancer, accounting for less than 1% of all pancreatic tumors. Preoperative diagnosis is cumbersome as cross-sectional imaging is often not capable to distinguish between UC-OGC and other pancreatic tumors such as pancreatic adenocarcinoma, mucinous carcinoma or neuroendocrine tumors and specific tumor markers seem to be lacking. Endoscopic ultrasound r `m(EUS) with tissue acquisition via fine-needle aspiration (FNA) or biopsy (FNB) with microscopic HE staining and immunohistochemistry allows for an accurate diagnosis, thus influencing further treatment. We present herein the cases of two patients with osteoclast-like giant cells tumors of the pancreas diagnosed by EUS-guided fine needle biopsy and perform a literature review on the role of EUS-guided biopsy for diagnosis.

Publisher

Walter de Gruyter GmbH

Link

https://www.sciendo.com/pdf/10.2478/rjim-2023-0008

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