DNA Cleavage and Cytotoxic Activity of Copper(II) Complexes Based on Reduced Schiff Bases Derived From Salicylaldehyde and Amino Acids-Reference-Cited by-同舟云学术

DNA Cleavage and Cytotoxic Activity of Copper(II) Complexes Based on Reduced Schiff Bases Derived From Salicylaldehyde and Amino Acids

Published:2023-12-01 Issue:s2 Volume:70 Page:48-51
ISSN:2453-6725
Container-title:European Pharmaceutical Journal
language:en
Short-container-title:

Author:

Korcová Jana¹,Húserková Mária¹,Lintnerová Lucia¹,Valentová Jindra¹

Affiliation:

1. Comenius University , Faculty of Pharmacy, Department of Chemical Theory of Drugs , Bratislava , Slovakia

Abstract

Abstract Metal complexes, which, under physiologic conditions, show redox properties and are able to bind to DNA, are great tools to cleave the DNA chain. This aspect is of great importance for their use as antineoplastic drugs. We synthesized ligands derived from short-chain amino acids and from salicylaldehyde. The prepared ligands of the type of reduced Schiff bases were subsequently used for the preparation of copper(II) complexes. The aim of the study was in vitro testing of copper(II) complexes, where it was confirmed that they are capable of cleaving DNA. Their cytotoxic activity was also confirmed by the resazurin redox method on Saccharomyces cerevisiae based on preserved healthy mitochondrial function.

Publisher

Walter de Gruyter GmbH

Link

https://www.sciendo.com/pdf/10.2478/afpuc-2024-0003

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