Quantitative Morphology as a Prognostic Factor in Feline Spontaneous Cutaneous Squamous Cell Carcinomas-Reference-Cited by-同舟云学术

Quantitative Morphology as a Prognostic Factor in Feline Spontaneous Cutaneous Squamous Cell Carcinomas

Published:2018-09-01 Issue:3 Volume:68 Page:251-256
ISSN:1820-7448
Container-title:Acta Veterinaria
language:en
Short-container-title:

Author:

Radostina Simeonov¹

Affiliation:

1. Department of General and Clinical Pathology, Faculty of Veterinary Medicine, Trakia University, Stara Zagora , Bulgaria

Abstract

Abstract In a study on cytological specimens from 30 cats with histologically confi rmed cutaneous squamous cell carcinoma, the morphometric variables mean nuclear area (MNA, μm2), mean nuclear perimeter (MNP, μm), mean nuclear diameter (D mean, μm), minimum nuclear diameter (D min, μm) and maximum nuclear diameter (D max, μm) were studied and compared to metastases in regional lymph nodes. The mean values of these parameters were signifi cantly greater in cats with lymph node metastases compared to parameters of tumour cells from cats which were lymph node-negative. A signifi cant positive correlation was observed between all studied morphometric parameters and metastases in the regional lymph nodes. In conclusion, computer -assisted nuclear morphometry could be used as a prognostic method in the diagnosis of spontaneous feline cutaneous squamous cell carcinomas.

Publisher

Walter de Gruyter GmbH

Subject

General Veterinary

Link

https://www.sciendo.com/pdf/10.2478/acve-2018-0022

Reference14 articles.

1. 1. Goldschmidt M, Dunstan R, Stannard A, von Tscharner C, Walder E, Yager, J: Histologic Classifi cation of Tumors of the Skin of Domestic Animals, World Health Organization International Classifi cation of Tumors of Domestic Animals, Second Series, Vol III, Washington, D.C., Armed Forces Institute of Pathology, American Registry of Pathology, 1998.

2. 2. Schwegler K., Walter J, Rudolph, R: Epithelial neoplasms of the skin, the cutaneous mucosa ant the transitional epithelium in dogs: an immunolocalization study for papilomavirus antigen. Zentral Vetertinarmed A 1997, 44:115-123, 1997.

3. 3. Goldschmidt M, Shofer F: Squamous cell carcinoma. In: Skin Tumours of Dogs and Cat. Oxford, Reed Educational and Professional Publishing Ltd, 1998.

4. 4. Goldschmidt, M, Goldschmidt K: In: Tumors in Domestic Animals, 5 th Edition, John Wiley & Sons 2017, 88-142.10.1002/9781119181200.ch4

5. 5. Theon A, Madewell B, Shearn, V: Prognostic factors assosiated with radiotherapy of squamous cell carcinoma of the nasal plane in cats. J Am Vet Med Assoc 1995, 196:991-996.