Effects of relaxation breathing exercise on fatigue and cortisol level among Indonesian gynecological cancer patients undergoing chemotherapy: a pilot study

Author:

Mulhaeriah Mulhaeriah1,Sangkala Mohammad Syafar2,Syahrul Syahrul2,Wahyuni Rezki3

Affiliation:

1. Department of Maternity Nursing, Faculty of Nursing, Hasanuddin University , Makassar , South Sulawesi , Indonesia

2. Department of Medical Surgical Nursing, Faculty of Nursing, Hasanuddin University , Makassar , South Sulawesi , Indonesia

3. Hasanuddin University Hospital , Makassar , South Sulawesi , Indonesia

Abstract

Abstract Objective This study aimed to determine the effect of the relaxation breathing exercise (RBE) on fatigue and cortisol levels among Indonesian women with gynecological cancer undergoing chemotherapy. Methods This pilot study consecutively recruited 44 gynecological cancer patients to receive RBE (22) or usual care (22). Cortisol level was measured before and after completion of the intervention (day 8). Fatigue was measured using the Piper Fatigue Scale (PFS). Anxiety and depression were assessed using the Hospital Anxiety and Depression Scale (HADS) at the baseline days of the study for days 1, 4, and 8. The obtained data were analyzed using Fisher’s exact test, the independent t-test, and the Mann–Whitney U test. Results There were significant increases in cortisol levels within the groups, either the intervention or control groups, respectively (P-value = 0.0003 and 0.001). Despite there being no statistical significance between the intervention and control groups, there were noticeable differences in the cortisol levels, indicating the extreme increase in cortisol levels in the control group (Median [IQR1– IQR3]: 2.30 [0.99–9.09]; Min–Max: 0.43–23.38) compared with the intervention group (Median [IQR1–IQR3] = 2.97 [1.26–5.18]; Min–Max = 0.39–6.91). Conclusions RBE helps prevent a significant increase in cortisol levels that can alleviate fatigue for women with gynecological cancer. Further research was recommended to compare several intervention modalities for fatigue and cancer-related symptom management based on cortisol level changes.

Publisher

Walter de Gruyter GmbH

Reference45 articles.

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2. Sung H, Ferlay J, Siegel RL, et al. Global Cancer Statistics 2020: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA Cancer J Clin. 2021;71:209–249.

3. World Health Organization (WHO). Cancer today 2022. https://gco.iarc.fr/today/online-analysis-pie. Accessed July 20, 2022.

4. World Health Organization (WHO). Cervical cancer Indonesia 2021 country profile 2021. https://www.who.int/publications/m/item/cervical-cancer-idn-country-profile-2021. Accessed August 6, 2022.

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