Role of the Nitric Oxide (NO) in the Regulation of Steroidogenesis in Placenta During Physiological Pregnancy and Preeclampsia (Experimental Study)-Reference-Cited by-同舟云学术

Role of the Nitric Oxide (NO) in the Regulation of Steroidogenesis in Placenta During Physiological Pregnancy and Preeclampsia (Experimental Study)

Published:2019-12-01 Issue:1 Volume:42 Page:1-11
ISSN:2084-1892
Container-title:Current Topics in Biophysics
language:en
Short-container-title:

Author:

Sanikidze Tamar V.¹,Cheishvili Levan A.¹,Kipiani Nana V.¹,Shekiladze Eka R.¹²,Kipiani Nina V.¹,Sharashenidze Gubaz Z.¹,Chikvaidze Eduard N.²

Affiliation:

1. Tbilisi State Medical University , 33, Vazha Pshavela Ave, 0186, Tbilisi , Georgia

2. Javakhishvili Tbilisi State University , 1, Chavchavadze Ave., 0179, Tbilisi , Georgia

Abstract

Abstract The aim of the study was to establish the role of nitric oxide (NO) in the regulation of steroidogenesis in the placenta during physiological pregnancy and experimental preeclampsia (PE) in rats. EPR centers of the placenta, free NO and its metabolites were determined by the Electron Paramagnetic Resonance (EPR) method. At the last stage of pregnancy in the EPR spectra of the rats’ placenta with PE alterations of the signals intensity of mitochondrial steroidogenic electron transport proteins were detected: the FeS-centers of adrenodoxin decreased, the ferricytochrome P-450 increased, the free NO content decreased, and the complexes of NO with heme (HbNO) and non-heme iron (FeSNO) were detected. These data indicate the violation of placental steroidogenesis, which is confirmed by a decrease in the level of progesterone in blood. Therefore, the nitrosylation of mitochondrial proteins is an important redox-dependent mechanism of regulation of the intensity of steroidogenesis.

Publisher

Walter de Gruyter GmbH

Link

https://www.sciendo.com/pdf/10.2478/ctb-2019-0003

Reference69 articles.

1. Arpad Csapo I., Wiest Walter G. (1969). An Examination of the Quantitative Relationship Between progesterone and the Maintenance of Pregnancy. Endocrinology. 85(735), 735-746.

2. Baylis S.A., Strijbos P.J., Sandra A., Russell R.J., Rijhsinghani A., Charles I.G., Weiner C.P. (1999). Temporal expression of inducible nitric oxide synthase in mouse and human placenta. Mol. Hum. Reprod. 5(3), 277-86.

3. Beridze M., Sanikidze T., Shakarishvilil R., Intskirveli N., Bornstein N.M. (2011). Selected acute phase CSF factors in ischemic stroke: findings and prognostic value. BMC neurology. 11(1), 41.

4. Brown G.C. (1995). Nitric oxide regulates mitochondrial respiration and cell functions by inhibiting cytochrome oxidase. FEBS Lett.369, 136–139.

5. Cartwright J.E., Kenny L.C., Dash P.R., Crocker I.P., Aplin J.D., Baker P.N., Whitley G.S. (2002). Trophoblast Invasion of spiral arteries: a novel in vitro model. Placenta. 23(2-3), 232-5.

Cited by 1 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. Nitric oxide synthase and its function in animal reproduction: an update;Frontiers in Physiology;2023-11-07