The Role of Gut Microbiota in Obesity

Author:

Durma Anna Celina1ORCID,Durma Adam Daniel2ORCID,Smialowski Adam3ORCID,Czupryniak Leszek1ORCID

Affiliation:

1. Department of Diabetology and Internal Medicine, Medical University of Warsaw , Warsaw , Poland

2. Department of Endocrinology and Radioisotope Therapy, Military Institute of Medicine – National Research Institute , Warsaw , Poland

3. Department of Endocrinology and Metabolic Diseases, Polish Mother’s Memorial Hospital, Research Institute; Medical University of Lodz , Lodz , Poland

Abstract

Abstract Obesity is a disease which is currently one of the most serious problems affecting approximately 650 million people worldwide. Improper lifestyle is considered the primary cause of the disease; however, many other factors contribute to the problem. In recent years, attention has been drawn to the role of gut microbiota in developing and controlling obesity and overweight. Microorganisms in the gastrointestinal tract are responsible for the fermentation of certain nutrients, causing efficient digestion, stimulation of intestinal transit, vitamin production, and modulation of the host’s immune system. Numerous studies have demonstrated that gut microbiota composition differs between obese individuals and those with a normal body mass index (BMI). It has also been shown that altering gut microbiota can influence the phenotype of the host organism, promoting metabolic changes, including BMI reduction. Recent studies aimed at using probiotics to modify gut microbiota composition to reduce body weight are still inconclusive.

Publisher

Walter de Gruyter GmbH

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