Unveiling metabolic flux changes during acute cold exposure-Reference-Cited by-同舟云学术

Unveiling metabolic flux changes during acute cold exposure

Published:2023-12-01 Issue:4 Volume:3 Page:193-195
ISSN:2719-8073
Container-title:Frigid Zone Medicine
language:en
Short-container-title:

Author:

Tang Pingping¹,Xu Henghui¹,Zhang Yong¹²³⁴

Affiliation:

1. Department of Pharmacology (State-Province Key Laboratories of Biomedicine-Pharmaceutics of China, Key Laboratory of Cardiovascular Research, Ministry of Education), College of Pharmacy, Harbin Medical University , Harbin , China

2. State Key Laboratory of Frigid Zone Cardiovascular Diseases (SKLFZCD) , Harbin , China

3. Research Unit of Noninfectious Chronic Diseases in Frigid Zone, Chinese Academy of Medical Sciences , 2019RU070 , Harbin , China

4. Institute of Metabolic Disease, Heilongjiang Academy of Medical Science , Harbin , China

Abstract

Abstract Controlling energy expenditure during acute cold exposure is a fundamental aspect of metabolic dynamics in organisms. However, prior studies on cold-induced thermogenesis faced limitations, primarily focusing on brown adipose tissue (BAT) and lacking precise in vivo flux measurements. This editorial aims to highlight the recent research by Bornstein et al. providing a comprehensive and quantitative insight into the intricate alterations in metabolic flux that drive this phenomenon[1].

Publisher

Walter de Gruyter GmbH

Link

https://www.degruyter.com/document/doi/10.2478/fzm-2023-0024/pdf

Reference10 articles.

1. Bornstein M R, Neinast M D, Zeng X, et al. Comprehensive quantification of metabolic flux during acute cold stress in mice. Cell Metab, 2023; 35(11): 2077-2092.

2. Jain R, Wade G, Ong I, et al. Determination of tissue contributions to the circulating lipid pool in cold exposure via systematic assessment of lipid profiles. J Lipid Res, 2022; 63(7): 100197.

3. Cannon B, Nedergaard J. Brown adipose tissue: function and physiological significance. Physiol Rev, 2004; 84(1): 277-359.

4. Blondin D P, Frisch F, Phoenix S, et al. Inhibition of intracellular triglyceride lipolysis suppresses cold-induced brown adipose tissue metabolism and increases shivering in humans. Cell Metab, 2017; 25(2): 438-447.

5. Rines A K, Sharabi K, Tavares C D, et al. Targeting hepatic glucose metabolism in the treatment of type 2 diabetes. Nat Rev Drug Discov, 2016; 15(11): 786-804.