Fabrication of PDMS chips by laser engraving for protein enrichments-Reference-Cited by-同舟云学术

Fabrication of PDMS chips by laser engraving for protein enrichments

Published:2022-02-01 Issue:1 Volume:73 Page:43-49
ISSN:1339-309X
Container-title:Journal of Electrical Engineering
language:en
Short-container-title:

Author:

Sun Linlin¹²,Ding Ao¹,Chen Yangbo³,Yang Xue¹,Yin Zhifu¹³,Fang Yuqiang¹

Affiliation:

1. School of Mechanical and Aerospace Engineering , Jilin University , Changchun , China

2. State Key Laboratory of Luminescent Materials and Devices , South China University of Technology , Guangzhou , China

3. The State Key Laboratory of Alternate Electrical Power System with Renewable Energy Sources , North China Electric Power University , Beijing , , China

Abstract

Abstract PDMS (Polydimethylsiloxane) chips are increasingly important for the application of fluorescence measurements due to their auto-fluorescence free, excellent transparency, and biocompatibility. However, the design of PDMS microfluidic chips requires to fabricate plenty of molds for structure optimization, resulting in high cost. In the present, PDMS chips with nafion membrane were fabricated by simple and low-cost method for bull serum albumin (BSA) enrichment. To optimize the laser cutting and bonding parameters, simulation models were established using Bilinear Kinematic and Mooney-Rivlin models, respectively. The influence of laser power and cutting speed on the width and depth of the micro-channels was investigated. And the effect of bonding pressure on the deformation of PDMS micro-channel and stress distribution near the micro-channels was also analyzed. The leakage test and BSA enrichment demonstrated the practicability and feasibility of the present fabrication method in this work.

Publisher

Walter de Gruyter GmbH

Link

https://www.sciendo.com/pdf/10.2478/jee-2022-0006

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