Thiol/Disulfide homeostasis in patients with rheumatoid arthritis-Reference-Cited by-同舟云学术

Thiol/Disulfide homeostasis in patients with rheumatoid arthritis

Published:2019-03-01 Issue:1 Volume:57 Page:30-36
ISSN:2501-062X
Container-title:Romanian Journal of Internal Medicine
language:en
Short-container-title:

Author:

Tuzcu Ayca¹,Baykara Rabia Aydogan²,Omma Ahmet³,Acet Gunseli Karaca²,Dogan Erdal⁴,Cure Medine Cumhur⁵,Sandikci Sevinc Can⁶,Cure Erkan⁷,Neşelioğlu Salim⁸,Erel Ozcan⁸

Affiliation:

1. Department of Biochemistry, Malatya Education and Research Hospital , Malatya , Turkey

2. Department of Physical Medicine and Rehabilitation, Malatya Education and Research Hospital , Malatya , Turkey

3. Division of Rheumatology, Department of Internal Medicine, Numune Education and Research Hospital , Ankara , Turkey

4. Department of Physical Medicine and Rehabilitation, Malatya Park Private Hospital , Malatya , Turkey

5. Department of Biochemistry , Istanbul Laboratory , Istanbul Turkey

6. Division of Rheumatology, Department of Internal Medicine, Diskapi Yildirim Beyazit Training and Research Hospital , Ankara , Turkey

7. Department of Internal Medicine, Camlica Erdem Hospital , Istanbul , Turkey

8. Department of Clinical Biochemistry, Faculty of Medicine , Yildirim Beyazit University , Ankara , Turkey

Abstract

Abstract Background . Oxidative stress may play an important role in rheumatoid arthritis (RA) etiopathogenesis. The thiol group is a very strong antioxidant. In this study, we aimed to investigate the presence of oxidative stress in patients with RA by evaluating thiol/disulfide homeostasis. Material and methods . A total of 50 female RA patients and 50 healthy female controls were included in this study. Thiol and disulfide values were calculated utilizing novel methods. Results . Native thiol (p < 0.001) and total thiol (p < 0.001) levels of RA patients were significantly lower compared to values in the control group. However, the disulfide (p < 0.001) levels of RA patients were strongly higher than in healthy individuals. A negative correlation was found between thiol and disease activity score-28 among the patients, whereas a positive correlation was found between disulfide and disease activity score-28 among the patients. Conclusion . We found that the thiol–disulfide rate deteriorated in RA patients, with the proportion of disulfide increasing. There is a strong correlation between the decrease in thiol levels, increase in disulfide levels and the disease activity scores.

Publisher

Walter de Gruyter GmbH

Link

https://www.sciendo.com/pdf/10.2478/rjim-2018-0025

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