Modulatory Role of Galectin-1 in Ulcerative Colitis with Comorbid Metabolic Syndrome-Reference-Cited by-同舟云学术

Modulatory Role of Galectin-1 in Ulcerative Colitis with Comorbid Metabolic Syndrome

Published:2023-08-01 Issue:0 Volume:0 Page:
ISSN:2956-0454
Container-title:Experimental and Applied Biomedical Research (EABR)
language:en
Short-container-title:

Author:

Corovic Kemal¹,Stojanovic Bojan²,Petrovic Andjela³,Stanisavljevic Isidora³,Maric Veljko⁴,Zdravkovic Natasa⁵,Jovanovic Marina⁵

Affiliation:

1. 1 Health Center Tutin , Serbia

2. 2 University of Kragujevac, Faculty of Medical Sciences , Department of Surgery , Kragujevac , Serbia

3. 3 University of Kragujevac , Serbia , Faculty of Medical Sciences, Center for Molecular Medicine and Stem Cell Research

4. 4 University of East Sarajevo, BiH , Medical faculty, Department of Surgery

5. 5 University of Kragujevac , Serbia , Faculty of Medical Sciences, Department of Internal medicine

Abstract

Abstract Metabolic syndrome (MetS) and ulcerative colitis (UC) are widespread health conditions characterized by chronic, low-grade inflammation. Galectin-1 (Gal-1), an immunomodulatory peptide mainly secreted from adipose tissue, could potentially play a crucial role in mitigating these conditions. This cross-sectional study explores the involvement of Gal-1 in MetS and UC within a cohort of 75 patients, newly diagnosed with UC. The MetS subgroup displayed increased fecal Gal-1 levels compared to those without MetS. Furthermore, Gal-1 showed predominance over pro-inflammatory cytokines, including TNF-α, IL-6, and IL-17, in these subjects. These findings emphasize the potential involvement of Gal-1 in the pathophysiology of UC and MetS, presenting it as a promising diagnostic biomarker and therapeutic target for these conditions.

Publisher

Walter de Gruyter GmbH

Link

https://www.sciendo.com/pdf/10.2478/eabr-2023-0006

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