Determination of the Relationship Between DNA Methylation Status of <i>KLOTHO</i> and <i>ARNTL</i> Genes With Hypertension-Reference-Cited by-同舟云学术

Determination of the Relationship Between DNA Methylation Status of KLOTHO and ARNTL Genes With Hypertension

Published:2023-12-01 Issue:2 Volume:26 Page:41-50
ISSN:1311-0160
Container-title:Balkan Journal of Medical Genetics
language:en
Short-container-title:

Author:

Osum M¹,Tosun O²,Birtan H³,Kalkan R⁴

Affiliation:

1. Department of Molecular Biology and Genetics, Faculty of Arts and Sciences , Near East University , Mersin 10 , Nicosia , Turkey

2. Department of Biostatistics, Faculty of Medicine , Near East University , Mersin 10 , Nicosia , Turkey

3. Department of Cardiovascular Surgery, Dr Burhan Nalbantoglu State Hospital , Nicosia Cyprus , Turkey

4. Faculty of Medicine , European University of Lefke , Mersin 10 , Lefke , Northern Cyprus , Turkey

Abstract

Abstract Hypertension is a multifactorial chronic disease due to the interaction of environmental factors with genetic alteration. KLOTHO and ARNTL genes play an important role in the development of hypertension. Therefore, we analyzed the methylation status of KLOTHO and ARNTL genes by using methylation-sensitive high-resolution melting (MSHRM) in a total of 78 hypertensive and 49 control subjects. In this study, we could not identify a significant association between KLOTHO and ARNTL methylation and the hypertensive phenotype. Moreover, we could not find a direct association between KLOTHO and ARNTL methylation and the fasting blood sugar, triglycerides, total cholesterol, LDL-cholesterol, HDL-cholesterol, sodium (Na), creatinine (Cr), potassium (K), and urea levels in hypertensive patients. However, we found a significant difference between the methylated KLOTHO hypertensive patients and the unmethylated KLOTHO control subjects for potassium (K).

Publisher

Walter de Gruyter GmbH

Link

https://www.sciendo.com/pdf/10.2478/bjmg-2023-0024

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